Product Name	SLC22A2
Chinese Name	溶质载体家族蛋白22成员A2抗体
Alias	MGC32628; OCT 2; OCT2; Organic cation transporter 2; Organic cation transporter; RP11-317M22.2; Solute carrier family 22 (organic cation transporter) member 2; Solute carrier family 22 member 2.
literatures	Specific References  (1)     |     SL19806R has been referenced in 1 publications. [IF=4.321] Ying Zhang. et al. mPEG2k-PCLx Polymeric Micelles Influence Pharmacokinetics and Hypoglycemic Efficacy of Metformin through Inhibition of Organic Cation Transporters in Rats. Mol Pharmaceut. 2021;XXXX(XXX):XXX-XXX  IF ;  Human.   PubMed:34102842
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC22A2: 51-150/555 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008] Function: SLC22A2 (solute carrier family 22 (organic cation transporter), member 2) is an organic cation transporter. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. SLC22A2 is found primarily in the kidney, where it may mediate the first step in cation reabsorption. It plays important roles in the renal tubular secretion of cationic drugs. Subcellular Location: Plasma membrane Similarity: Belongs to the major facilitator (TC 2.A.1)superfamily. Organic cation transporter (TC 2.A.1.19) family. SWISS: O15244 Gene ID: 6582 Database links: Entrez Gene: 6582 Human Entrez Gene: 20518 Mouse Entrez Gene: 29503 Rat Omim: 602608 Human SwissProt: O15244 Human SwissProt: O70577 Mouse SwissProt: Q9R0W2 Rat Unigene: 436385 Human

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