Product Name	SLC12A4
Chinese Name	溶质载体家族蛋白12成员A4抗体
Alias	Electroneutral potassium chloride cotransporter 1; Electroneutral potassium-chloride cotransporter 1; Erythroid K Cl cotransporter 1; Erythroid K-Cl cotransporter 1; FLJ40489; hKCC 1; hKCC1; KCC 1; KCC1; Potassium transport protein; Potassium/chloride cotransporter 1; S12A4_HUMAN; Slc12a4; Solute carrier family 12 (potassium/chloride transporters) member 4; Solute carrier family 12 member 4.
Research Area	Tumour  Cell biology  Signal transduction  Channel protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	121kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC12A4: 951-1050/1085
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013] Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity. Subcellular Location: Membrane. Tissue Specificity: Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes. Post-translational modifications: N-glycosylated. Similarity: Belongs to the SLC12A transporter family. SWISS: Q9UP95 Gene ID: 6560 Database links: Entrez Gene: 6560 Human Entrez Gene: 20498 Mouse Entrez Gene: 396992 Pig Entrez Gene: 29501 Rat Omim: 604119 Human SwissProt: Q9UP95 Human SwissProt: Q9JIS8 Mouse SwissProt: Q28677 Rabbit SwissProt: Q63632 Rat Unigene: 10094 Human Unigene: 292447 Mouse Unigene: 32091 Rat

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