Product Name	SH3BP5
Chinese Name	SH3结构域Binding protein5抗体
Alias	3BP5_HUMAN; OTTHUMP00000208289; OTTHUMP00000208291; OTTHUMP00000208294; SAB; SH3 binding protein; SH3 domain binding protein 5 (BTK associated); SH3 domain binding protein 5; SH3 domain binding protein that preferentially associates with BTK; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3 domainbinding protein 5; SH3BP 5; SH3BP-5; Sh3bp5.
Research Area	Cell biology  Signal transduction  Apoptosis  Kinases and Phosphatases  lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SH3BP5: 1-100/455
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Subcellular Location: Mitochondrion. Tissue Specificity: Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. Similarity: Belongs to the SH3BP5 family. SWISS: O60239 Gene ID: 9467 Database links: Entrez Gene: 9467 Human Entrez Gene: 520254 Cow Entrez Gene: 80851 Human Entrez Gene: 24056 Mouse Entrez Gene: 79566 Mouse Entrez Gene: 117186 Rat Omim: 605612 Human SwissProt: Q0V8K7 Cow SwissProt: O60239 Human SwissProt: Q7L8J4 Human SwissProt: Q99LH9 Mouse SwissProt: Q9Z131 Mouse SwissProt: Q91Y80 Rat Unigene: 11005 Cow Unigene: 257761 Human Unigene: 726063 Human Unigene: 290534 Mouse Unigene: 383198 Mouse Unigene: 163321 Rat
Product Picture	Sample: Ovary (Mouse) Lysate at 40 ug Testis (Mouse) Lysate at 40 ug Jurkat (Human) Cell Lysate at 30 ug Primary: Anti-SH3BP5 (SL19752R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD

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