Product Name	SH3BP4
Chinese Name	SH3结构域Binding protein4抗体
Alias	BOG25; EH binding protein; EH binding protein 10; EH-binding protein 10; EHB10; SH3 domain binding protein 4; SH3 domain-binding protein 4; SH3B4_HUMAN; sh3bp4; Transferrin receptor trafficking protein; Transferrin receptor-trafficking protein; TTP.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	107kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SH3BP4: 561-660/963
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008] Function: Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Subcellular Location: Membrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus. Tissue Specificity: Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). Post-translational modifications: Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2. Similarity: Contains 1 SH3 domain. SWISS: Q9P0V3 Gene ID: 516777 Database links: Entrez Gene: 520462 Cow Entrez Gene: 486172 Dog Entrez Gene: 100730563 Guinea pig Entrez Gene: 100065797 Horse Entrez Gene: 23677 Human Entrez Gene: 98402 Mouse Entrez Gene: 100347097 Rabbit Entrez Gene: 64634 Rat Omim: 605611 Human SwissProt: Q9P0V3 Human SwissProt: Q921I6 Mouse SwissProt: Q9JJS5 Rat Unigene: 516777 Human Unigene: 170983 Mouse Unigene: 35396 Rat Unigene: 36062 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat prostate); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SH3BP4) Polyclonal Antibody, Unconjugated (SL19751R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SH3BP4) Polyclonal Antibody, Unconjugated (SL19751R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SH3BP4) Polyclonal Antibody, Unconjugated (SL19751R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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