Product Name	SerpinB8
Chinese Name	丝氨酸蛋白酶抑制剂B8抗体
Alias	CAP 2; CAP-2; CAP2; Cytoplasmic antiproteinase 2; OTTHUMP00000067000; OTTHUMP00000067001; Peptidase inhibitor 8; PI 8; PI-8; PI8; Protease inhibitor 8 (ovalbumin type); Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8; Serpin B8; Serpin peptidase inhibitor clade B (ovalbumin) member 8; Serpinb8; SPB8_HUMAN.
Research Area	Cell biology  immunology  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Cat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SerpinB8: 121-220/374
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010] Subcellular Location: Cytoplasm. Similarity: Belongs to the serpin family. Ov-serpin subfamily. SWISS: P50452 Gene ID: 5271 Database links: Entrez Gene: 5271 Human Entrez Gene: 20725 Mouse Entrez Gene: 288937 Rat Omim: 601697 Human SwissProt: P50452 Human SwissProt: O08800 Mouse Unigene: 368077 Human Unigene: 83909 Mouse Unigene: 104823 Rat
Product Picture	Sample: SW480(human) Cell Lysate at 40 ug Primary: Anti-SerpinB8 (SL19660R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kD Observed band size: 43 kD

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