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Product Name KLK4 Chinese Name 激肽释放酶4抗体 Alias Kallikrein 4; 7S nerve growth factor alpha chain; AI2A1; Alpha-NGF; Androgen-regulated message 1; ARM1; EC 3.4.21.-; EMSP 1; EMSP; EMSP1; Enamel Matrix Serine Protease 1; Enamel matrix serine proteinase 1; HK4; Kallikrein 1-related peptidase-like b4; Kallikrein 4 (prostase, enamel matrix, prostate); Kallikrein; Kallikrein L1; Kallikrein like protein 1; Kallikrein like protein 1; Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate); Kallikrein-4; Kallikrein-like protein 1; Kallikrein-related peptidase 4; KLK 4; KLK L1; KLK-L1; KLK4; KLK4_HUMAN; MGC116827; MGC116828; Prostase; Protease Serine 17; PRSS 17; PRSS17; PSTS; Serine protease 17. literatures Specific References (1) | SL1965R has been referenced in 1 publications.[IF=3.606] Xie, Yongting. et al. Amelogenesis imperfecta in a Chinese family resulting from a FAM83H variation and the effect of FAM83H on the secretion of enamel matrix proteins. CLIN ORAL INVEST. 2022 Nov;:1-11 WB ; Rat.Research Area Tumour Cell biology Signal transduction Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Rabbit, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 24kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KLK4: 101-200/254 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq].
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in prostate.
DISEASE:
Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
SWISS:
Q9Y5K2
Gene ID:
9622
Database links:Entrez Gene: 9622 Human
Entrez Gene: 56640 Mouse
Omim: 603767 Human
SwissProt: Q9Y5K2 Human
SwissProt: P00757 Mouse
Unigene: 218366 Human
Unigene: 42080 Mouse
KLK4目前认为是前列腺癌等其他Tumour很有意义的Maker。激肽释放酶KLK是激肽系统的主要限速酶,它是一组存在于多数组织和体液中的丝氨酸蛋白酶,是一种肽链内切酶。KLK又称血管舒缓素,包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽,可裂解激肽原释放具有活性的激肽,由激肽发挥对Cardiovascular系统及肾脏功能的调节作用。
组织KLK是一个大的基因家族,主要分布在肺、肾、血管、脑、肾上腺组织,为一种中等大小的glycoprotein。
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