Product Name	SENP2
Chinese Name	Ubiquitin样蛋白特异性蛋白酶2抗体
Alias	Axam2; DKFZp762A2316; KIAA1331; Senp2; SERP2; SENP2_HUMAN; Sentrin specific protease 2; Sentrin-specific protease 2; Sentrin/SUMO specific protease SENP2; Sentrin/SUMO-specific protease SENP2; SMT3 specific isopeptidase 2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific peptidase 2.
Research Area	Cell biology  Signal transduction  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SENP2: 1-100/589
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004] Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Subcellular Location: Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus. Post-translational modifications: Polyubiquitinated; which leads to proteasomal degradation. Similarity: Belongs to the peptidase C48 family. SWISS: Q9HC62 Gene ID: 59343 Database links: Entrez Gene: 59343 Human Entrez Gene: 75826 Mouse Entrez Gene: 78973 Rat Omim: 608261 Human SwissProt: Q9HC62 Human SwissProt: Q91ZX6 Mouse SwissProt: Q9EQE1 Rat Unigene: 401388 Human Unigene: 297431 Mouse Unigene: 9367 Rat
Product Picture	Protein: lung(mouse) lysate at 40ug; Primary: rabbit Anti-SENP2(SL19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 63 kD Protein: bone(mouse) lysate at 40ug; Primary: rabbit Anti-SENP2(SL19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 63 kD

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