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Product Name SDHAF1 Chinese Name 琥珀酸脱氢酶的组合因子1抗体 Alias LYR motif containing 8; LYR motif-containing protein 8; LYRM8; mitochondrial; SDH assembly factor 1; SDHAF1; SDHF1_HUMAN; Succinate dehydrogenase assembly factor 1; Succinate dehydrogenase assembly factor 1 mitochondrial; Succinate dehydrogenase complex assembly factor 1. Research Area Cell biology Neurobiology Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SDHAF1: 1-100/115 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
Function:
Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II.
Subcellular Location:
Mitochondrion matrix.
Tissue Specificity:
Ubiquitously expressed.
DISEASE:
Mitochondrial complex II deficiency
Similarity:
Belongs to the complex I LYR family. SDHAF1 subfamily.
SWISS:
A6NFY7
Gene ID:
644096
Database links:Entrez Gene: 644096 Human
Entrez Gene: 68332 Mouse
Omim: 612848 Human
SwissProt: A6NFY7 Human
SwissProt: Q3U276 Mouse
Unigene: 356460 Human
Unigene: 6844 Mouse
Unigene: 3527 Rat
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