Product Name	SAA1
Chinese Name	血清淀粉样蛋白A抗体
Alias	amyloid A, serum; Amyloid fibril protein AA; Amyloid protein A; MGC111216; PIG4; SAA; SAA1_HUMAN; Serum amyloid A protein; serum amyloid A-1 protein; serum amyloid A1; TP53I4; Tumor protein p53 inducible protein 4.
literatures	Specific References  (1)     |     SL19359R has been referenced in 1 publications. [IF=4.086] Kangxi Cao. et al. SAA1 Expression as a Potential Prognostic Marker of the Tumor Microenvironment in Glioblastoma. FRONT NEUROL. 2022; 13: 905561  WB ;  Human.   PubMed:35756918
Research Area	Tumour  Cell biology  immunology  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SAA1: 41-94/122
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012] Function: Major acute phase reactant. Apolipoprotein of the HDL complex. Subunit: Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver; secreted in plasma (at protein level). Post-translational modifications: This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end. DISEASE: Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. SWISS: P0DJI8 Gene ID: 6288 Database links: Entrez Gene: 6288 Human Entrez Gene: 20208 Mouse Omim: 104750 Human SwissProt: P0DJI8 Human SwissProt: P05366 Mouse Unigene: 632144 Human Unigene: 148800 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SAA1/Serum Amyloid A) Polyclonal Antibody, Unconjugated (SL19359R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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