TEL: +86 571 56623320 EMAIL: [email protected]
Product Name NRG4 Chinese Name 神经调节蛋白4抗体 Alias DKFZp779N0541; DKFZp779N1944; Heregulin 4; HRG4; Neuregulin 4; Neuregulin-4; NRG-4; NRG4; NRG4_HUMAN; pro-neuregulin-4, membrane-bound isoform; Pro-NRG4. Research Area Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 13kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NRG4: 1-100/115 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular Location:
Secreted and Cell membrane. Does not seem to be active.
Post-translational modifications:
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage.
Similarity:
Belongs to the neuregulin family.
Contains 1 EGF-like domain.
SWISS:
Q8WWG1
Gene ID:
145957
Database links:Entrez Gene: 145957 Human
Entrez Gene: 83961 Mouse
Omim: 610894 Human
SwissProt: Q8WWG1 Human
SwissProt: Q9WTX4 Mouse
Unigene: 732438 Human
Unigene: 443874 Mouse
Unigene: 120491 Rat
Scan Wechat Qrcode