TEL: +86 571 56623320 EMAIL: [email protected]
Product Name NPAS4 Chinese Name 神经细胞PAS结构域蛋白4抗体 Alias bHLH PAS type transcription factor NXF; bHLHe79; bHLHe79; Class E basic helix-loop-helix protein 79; HLH-PAS transcription factor NXF; Le PAS; limbic enhanced PAS protein; neuronal PAS domain protein 4; Neuronal PAS domain-containing protein 4; Neuronal PAS4; NPAS4; NPAS4_HUMAN; NXF; PAS domain-containing protein 10; PASD10. Research Area Cell biology Neurobiology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 87kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NPAS4: 1-100/802 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
Function:
Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNT.
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
SWISS:
Q8IUM7
Gene ID:
266743
Database links:Entrez Gene: 266743 Human
Entrez Gene: 225872 Mouse
Entrez Gene: 724016 Zebrafish
Omim: 608554 Human
SwissProt: Q8IUM7 Human
SwissProt: Q8BGD7 Mouse
SwissProt: Q1ECW2 Zebrafish
Unigene: 256036 Human
Unigene: 287867 Mouse
Unigene: 86654 Rat
Unigene: 81110 Zebrafish
Scan Wechat Qrcode