TEL: +86 571 56623320 EMAIL: [email protected]
Product Name NOL9 Chinese Name 核仁蛋白9抗体 Alias FLJ23323; MGC131821; MGC138483; NET6; NOL9; Nucleolar protein 9. Research Area Cell biology immunology Chromatin and nuclear signals Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 79kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NOL9: 451-550/702 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail NOL9 is a 702 amino acid protein that resides within the nucleolus. The gene encoding NOL9 maps to human chromosome 1, which spans about 260 million base pairs, making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes, there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
Function:
Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.
Subunit:
Interacts with PELP1, WDR18 and SENP3.
Subcellular Location:
Nucleus; nucleolus
Similarity:
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
SWISS:
Q5SY16
Gene ID:
79707
Database links:Entrez Gene: 79707 Human
SwissProt: Q5SY16 Human
Scan Wechat Qrcode