Product Name	NFATC2IP
Chinese Name	活化TThe nucleus因子胞浆相互作用蛋白2抗体
Alias	45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60.
Research Area	Cell biology  Neurobiology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NFATC2IP: 171-270/419
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production. Subcellular Location: Nucleus. Cytoplasm. TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. Post-translational modifications: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. Similarity: Contains 1 ubiquitin-like domain. SWISS: Q8NCF5 Gene ID: 84901 Database links: Entrez Gene: 84901 Human Entrez Gene: 18020 Mouse Entrez Gene: 308983 Rat Omim: 614525 Human SwissProt: Q9GLZ9 Cynomolgus Monkey SwissProt: Q8NCF5 Human SwissProt: O09130 Mouse SwissProt: Q6AYG7 Rat Unigene: 513470 Human Unigene: 1389 Mouse Unigene: 101030 Rat

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