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Product Name NECAB3 Chinese Name 神经细胞钙Binding protein抗体 Alias Neuronal calcium-binding protein; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein; Amyloid beta A4 protein binding family A member 2 binding protein; Amyloid beta A4 protein-binding family A member 2-binding protein; APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; N terminal EF hand calcium binding protein 3; N-terminal EF-hand calcium-binding protein 3; NECA3_HUMAN; NECAB3; NECAB3; Nek2 interacting protein 1; Nek2-interacting protein 1; Neuronal calcium binding protein 3; Neuronal calcium-binding protein 3; NIP1; STIP3; Synaptotagmin interacting protein 2; SYTIP2; X11L binding protein 51; X11L-binding protein 51; XB51. Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 44kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NECAB3: 301-396/396 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.
Subcellular Location:
Golgi apparatus.
Tissue Specificity:
Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.
Post-translational modifications:
Phosphorylated by NEK2.
Similarity:
Contains 1 ABM domain.
Contains 1 EF-hand domain.
SWISS:
Q96P71
Gene ID:
63941
Database links:Entrez Gene: 63941 Human
Omim: 612478 Human
SwissProt: Q96P71 Human
Unigene: 516986 Human
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