Product Name	TFF2
Chinese Name	三叶肽因子2抗体
Alias	TFF2_HUMAN; Trefoil factor 2; SML1; SP; Spasmolysin; Spasmolytic polypeptide (SP);
Research Area	Cell biology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,
Applications	WB=1:200-1000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12/14kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TFF2: 51-129/129
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Function: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). Subcellular Location: Secreted. Tissue Specificity: Stomach. Similarity: Contains 2 P-type (trefoil) domains. SWISS: Q03403 Gene ID: 7032 Database links: Entrez Gene: 7032 Human Entrez Gene: 21785 Mouse Entrez Gene: 116592 Rat SwissProt: Q03403 Human SwissProt: Q03404 Mouse SwissProt: Q09030 Rat 三叶肽可能使黏膜凝胶产生更大的稳定性,使胃黏膜对各种损伤因子的防御能力增强。三叶肽在诱导上皮修复上的直接作用,可用于许多胃肠道疾病。它作为辅助剂或取代皮质类固醇或其他免疫抑制剂，在溃疡病及炎症性肠病的治疗上可能是一个突破。
Product Picture	Sample: Lane 1: Mouse Small intestine tissue lysates Lane 2: Mouse Pancreas tissue lysates Primary: Anti-TFF2 (SL1921R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 12-14 kDa Observed band size: 15 kDa Paraformaldehyde-fixed, paraffin embedded (Human stomach); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (TFF2) Polyclonal Antibody, Unconjugated (SL1921R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TFF2) Polyclonal Antibody, Unconjugated (SL1921R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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