Product Name	NEURL2
Chinese Name	E3Ubiquitin连接酶蛋白NEURL2抗体
Alias	Neuralized E3 Ubiquitin Protein Ligase 2; C20orf163; Chromosome 20 Open Reading Frame 163; Neuralized Homolog 2 (Drosophila) ; Neuralized-Like 2 (Drosophila); Neuralized-Like Protein 2; Neuralized Homolog 2; OZZ-E3; OZZ; NEUL2_HUMAN;
Research Area	Cell biology  Kinases and Phosphatases  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NEURL2: 1-100/285
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013] Function: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma By similarity. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed specifically in skeletal and cardiac muscles. Similarity: Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of TCEB2/Elongin B, TCEB1/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1 By similarity. SWISS: Q9BR09 Gene ID: 140825 Database links: Entrez Gene: 140825 Human Entrez Gene: 415115 Mouse Entrez Gene: 311633 Rat Omim: 608597 Human SwissProt: Q9BR09 Human SwissProt: Q9D0S4 Mouse

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