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Product Name Neurexophilin 3 Chinese Name 神经外营养蛋白3抗体 Alias KIAA1159; Neurexophilin-3; NPH3; Nxph3; NXPH-3; NXPH3_HUMAN; UNQ687/PRO1327. Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Neurexophilin 3: 1-100/252 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Neurexophilin-1-3 are secreted proteins that are thought to function as signaling molecules which specifically bind to target proteins, such as neurexin I Alpha(a protein that promotes adhesion between dendrites and axons), and are essential for proper neurotransmitter release. While Neurexophilin-1 is located primarily in spleen tissue, Neurexophilin-2 is expressed primarily in kidney and both Neurexophilin-2 and Neurexophilin-3 are highly expressed in brain. Defects in the gene encoding Neurexophilin-1 may be associated with schizophrenia, a mental disorder characterized by an abnormal perception of reality.
Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.
Subcellular Location:
Secreted.
Tissue Specificity:
Highest level in brain.
Post-translational modifications:
May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
Similarity:
Belongs to the neurexophilin family.
SWISS:
O95157
Gene ID:
11248
Database links:Entrez Gene: 11248 Human
Entrez Gene: 104079 Mouse
Omim: 604636 Human
SwissProt: O95157 Human
SwissProt: Q91VX5 Mouse
Unigene: 55069 Human
Unigene: 22970 Mouse
Unigene: 19736 Rat
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