Product Name	TGM3
Chinese Name	谷氨酰胺转胺酶3抗体
Alias	Transglutaminase 3; E polypeptide protein glutamine gamma glutamyltransferase; MGC126249; MGC126250; Protein glutamine gamma glutamyltransferase E 27 kDa catalytic chain; Protein glutamine gamma glutamyltransferase E 50 kDa noncatalytic chain; Protein glutamine gamma glutamyltransferase E; TG(E); TGase E; TGE; TGM 3; TGM3; Transglutaminase E; Transglutaminase3; TransglutaminaseE; TGM3_HUMAN.
literatures	Specific References  (1)     |     SL1911R has been referenced in 1 publications. [IF=2.47] Kawabe, Kenji, et al. "Transglutaminases Derived from Astrocytes Accelerate Amyloid β Aggregation." Neurochemical Research: 1-8.  Rat.   PubMed:28391388
Research Area	Neurobiology  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25/76kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TGM3: 601-693/693
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium dependent. Transglutaminase 3 consists of two polypeptide chains activated from a single precursor protein by proteolysis. Transglutaminase 3 is involved the later stages of cell envelope formation in the epidermis and hair follicle. Subunit: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide. Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family. SWISS: Q08188 Gene ID: 7053 Database links: Entrez Gene: 7053 Human Entrez Gene: 21818 Mouse Omim: 600238 Human SwissProt: Q08188 Human SwissProt: Q08189 Mouse Unigene: 2022 Human Unigene: 2961 Mouse TGM3是转谷氨酰胺酶家族的主要成员之一，是一种钙离子依赖性蛋白酶，主要功能是参与角质化细胞的终末分化过程。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TGM3) Polyclonal Antibody, Unconjugated (SL1911R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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