Product Name	Mus81
Chinese Name	核酸内切酶同源蛋白MUS81抗体
Alias	Crossover junction endonuclease MUS81; FLJ21012; FLJ44872; Mus 81; MUS81; MUS81 Endonuclease Homolog; MUS81_HUMAN.
Research Area	Cell biology  immunology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Mus81: 401-500/551
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MUS81 encodes a helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae (1). Mus81 is important for replicational stress tolerance in both budding and fission yeast (2). Specifically, Mus81 associates with Eme1 to form an endonuclease that can process stalled replication forks before they have regressed to form a Holliday junction (2–4). Mus81 associated endonuclease resolves Holliday junctions into linear duplexes by cutting across the junction exclusively on strands of like polarity (2). In addition, Mus81 protein abundance increases in cells following exposure to agents that block DNA replication (2). Mus81 is involved in the recruitment of Cds1 to aberrant DNA structures where Cds1 modulates the activity of damage tolerance enzymes (4). The gene encoding human MUS81 maps to chromosome 11q13 and encodes a 551 amino acid protein (5). Function: Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Subcellular Location: Nucleus > nucleolus. Recruited to foci of DNA damage in S-phase cells. Tissue Specificity: Widely expressed. Similarity: Belongs to the XPF family. Contains 1 ERCC4 domain. SWISS: Q96NY9 Gene ID: 80198 Database links: Entrez Gene: 80198 Human Entrez Gene: 528432 Cow Entrez Gene: 71711 Mouse Entrez Gene: 293678 Rat Omim: 606591 Human SwissProt: Q1JPC1 Cow SwissProt: Q2KIT9 Cow SwissProt: Q96NY9 Human SwissProt: Q91ZJ0 Mouse SwissProt: Q4KM32 Rat Unigene: 288798 Human Unigene: 27697 Mouse Unigene: 137652 Rat
Product Picture	Sample: HepG2 Cell (Human) Lysate at 40 ug Hela Cell (Human) Lysate at 40 ug Primary: Anti-Mus81 (SL19109R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kD Observed band size: 62 kD

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