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Product Name phospho-MERTK (Tyr749) Chinese Name 磷酸化c-mer原癌基因酪氨酸激酶抗体 Alias MERTK_HUMAN; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MER; MER proto-oncogene, tyrosine kinase; RP38; c-Eyk; c-mer; Tyro12. literatures Specific References (2) | SL18790R has been referenced in 2 publications.[IF=5.546] Yang H et al. Homeobox C8 inhibited the osteo‐/dentinogenic differentiation and migration ability of stem cells of the apical papilla via activating KDM1A. J Cell Physiol . 2020 Apr 4. IHC ; human.[IF=3.641] Arshad Zahoor et al. MerTK negatively regulates Staphylococcus aureus induced inflammatory response via Toll-like receptor signaling in the mammary gland. Mol Immunol . 2020 Apr 2;122:1-12. WB ; mouse.Product Type Phosphorylated anti Research Area Cell biology Neurobiology Signal transduction Kinases and Phosphatases t-lymphocyte b-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 108kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human MERTK around the phosphorylation site of Tyr749: KI(p-Y)SG Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
Function:
In case of filovirus infection, seems to function as a cell entry factor.
Subcellular Location:
Membrane.
Tissue Specificity:
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
DISEASE:
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
SWISS:
Q12866
Gene ID:
10461
Database links:Entrez Gene: 10461 Human
Omim: 604705 Human
SwissProt: Q12866 Human
Unigene: 306178 Human
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