Product Name	phospho-MERTK (Tyr749 + Tyr753 + Tyr754)
Chinese Name	磷酸化c-mer原癌基因酪氨酸激酶抗体
Alias	MERTK (phospho Y749 + Y753 + Y754); p-MERTK (phospho Y749 + Y753 + Y754); MERTK_HUMAN; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MER; MER proto-oncogene, tyrosine kinase; RP38; c-Eyk; c-mer; Tyro12.
literatures	Specific References  (1)     |     SL18791R has been referenced in 1 publications. [IF=17.694] Zhuang Wan-Ru. et al. Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity. NAT COMMUN. 2023 Mar;14(1):1-15  WB ;  Mouse.   PubMed:36966130
Product Type	Phosphorylated anti
Research Area	Cell biology  Neurobiology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	180kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human MERTK around the phosphorylation site of Tyr749 + Tyr753 + Tyr754: KI(p-Y)SGD(p-Y)(p-Y)RQ
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] Function: In case of filovirus infection, seems to function as a cell entry factor. Subcellular Location: Membrane. Tissue Specificity: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. DISEASE: Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. SWISS: Q12866 Gene ID: 10461 Database links: Entrez Gene: 10461 Human Omim: 604705 Human SwissProt: Q12866 Human Unigene: 306178 Human
Product Picture	Sample: DU145(Human) Cell Lysate at 30 ug Primary: Anti-phospho-MERTK (Tyr749 + Tyr753 + Tyr754) (SL18791R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 180 kD Observed band size: 180 kD

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