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Product Name MAP3K15 Chinese Name MAPK/ERK激酶激酶15抗体 Alias Apoptosis signal-regulating kinase 3; ASK3; bA723P2.3; FLJ16518; M3K15_HUMAN; Map3k15; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15; Mitogen activated protein kinase kinase kinase 15; Mitogen-activated protein kinase kinase kinase 15; OTTHUMP00000183504. Research Area Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 147kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAP3K15: 301-400/1313 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Function:
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
Tissue Specificity:
Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
SWISS:
Q6ZN16
Gene ID:
389840
Database links:Entrez Gene: 389840 Human
Entrez Gene: 270672 Mouse
Omim: 300820 Human
SwissProt: Q6ZN16 Human
SwissProt: A2AQW0 Mouse
Unigene: 713701 Human
Unigene: 386889 Mouse
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