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Product Name MAN2B2 Chinese Name 溶酶体α-甘露糖苷酶2抗体 Alias EC 3.2.1.24; Laman; Lysosomal acid alpha mannosidase; Lysosomal alpha mannosidase; MANB; Mannosidase alpha class 2B member 1; Mannosidase, alpha B; Mannosidase, alpha B. Research Area Tumour Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 111kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAN2B2: 581-680/1009 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail MAN2B2 is a 1,009 amino acid secreted protein that belongs to the glycosyl hydrolase 38 family. Expressed as multiple alternatively spliced isoforms, MAN2B2 uses zinc as a cofactor to catalyze the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannoside proteins. The gene encoding MAN2B2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Subcellular Location:
Secreted
SWISS:
Q9Y2E5
Gene ID:
23324
Database links:Entrez Gene: 23324 Human
SwissProt: Q9Y2E5 Human
Unigene: 188464 Human
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