Product Name	MFHA1/Malignant fibrous histiocytoma
Chinese Name	恶性纤维组织细胞瘤抗体
Alias	Malignant fibrous histiocytoma-amplified sequence 1; Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1; MFHA1_HUMAN; Mfhas1.
Research Area	Tumour  Cell biology  Cyclin  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Dog, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	117kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MFHA1/Malignant fibrous histiocytoma: 951-1052/1052
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008] Tissue Specificity: Ubiquitously expressed. Overexpressed in malignant fibrous histiocytomas. DISEASE: A chromosomal aberration involving MFHAS1 may be a cause of B-cell lymphoma. Translocation t(8;14)(p23.1;q21) with a cryptic exon named '14q21 element'. The resulting fusion protein named 'chimeric MASL1' is tumorigenic in nude mice. Similarity: Contains 13 LRR (leucine-rich) repeats. Contains 1 Roc domain. SWISS: Q9Y4C4 Gene ID: 9258 Database links: Entrez Gene: 9258 Human Entrez Gene: 52065 Mouse Entrez Gene: 306508 Rat SwissProt: Q9Y4C4 Human SwissProt: Q3V1N1 Mouse Unigene: 379414 Human Unigene: 103246 Mouse Unigene: 106316 Rat

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