Product Name	LPHN2
Chinese Name	蛛毒素受体2抗体
Alias	Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; CL2; KIAA0786; Latrophilin 1; Latrophilin 2; Latrophilin homolog 1; latrophilin homolog 2; LEC1; Lectomedin-1; LPH2; LPHH1; LPHN2_HUMAN.
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	160kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LPHN2: 531-630/1459
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008] Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis. Subunit: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. Post-translational modifications: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 olfactomedin-like domain. Contains 1 SUEL-type lectin domain. SWISS: O95490 Gene ID: 23266 Database links: Entrez Gene: 281278 Cow Entrez Gene: 100052932 Horse Entrez Gene: 23266 Human Entrez Gene: 100405265 Marmoset (common) Entrez Gene: 99633 Mouse Entrez Gene: 100013683 Opossum Entrez Gene: 100524685 Pig Entrez Gene: 100343149 Rabbit Entrez Gene: 171447 Rat Entrez Gene: 100551470 Turkey Omim: 607018 Human SwissProt: O97817 Cow SwissProt: O95490 Human SwissProt: Q8JZZ7 Mouse SwissProt: O88923 Rat Unigene: 24212 Human Unigene: 9776 Mouse Unigene: 12089 Rat

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