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Product Name LMOD1 Chinese Name 甲状腺相关眼病自身抗原抗体 Alias 1D; 64 kDa autoantigen 1D; 64 kDa autoantigen 1D3; 64 kDa autoantigen D1; 9530015K06Rik; D1; Leiomodin; Leiomodin-1; Lmod1; LMOD1_HUMAN; muscle form; SM LMOD; SM-Lmod; SMLMOD; Smooth muscle leiomodin; Thyroid associated ophthalmopathy autoantigen; Thyroid-associated ophthalmopathy autoantigen. Research Area Cell biology Neurobiology Signal transduction Cell type markers Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Cat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 67kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LMOD1: 251-350/600 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cytoplasm. Cytoplasm; cytoskeleton.
Tissue Specificity:
Smooth muscle (heart, skeletal muscle, colon and small intestine), a subset of striated muscle fibers, and at low level in thyroid.
Similarity:
Belongs to the tropomodulin family.
Contains 1 WH2 domain.
SWISS:
P29536
Gene ID:
25802
Database links:Entrez Gene: 25802 Human
Entrez Gene: 428540 Chicken
Entrez Gene: 100052019 Horse
Entrez Gene: 93689 Mouse
Omim: 602715 Human
SwissProt: P29536 Human
SwissProt: Q8BVA4 Mouse
Unigene: 519075 Human
Unigene: 180124 Mouse
Unigene: 66554 Rat
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