Product Name	LINGO3
Chinese Name	富含亮氨酸重复跨膜神经元3抗体
Alias	LINGO-3; hCG2040376; LERN2; Leucine rich repeat and Ig domain containing 3; Leucine rich repeat neuronal 6B; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine-rich repeat neuronal protein 2; Leucine-rich repeat neuronal protein 6B; LIGO3_HUMAN; LINGO3; LRRN6B.
Research Area	Cell biology  Neurobiology  Transmembrane protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LINGO3: 351-450/592 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Lingo-3 is a 592 amino acid single-pass type I membrane protein. Lingo-3 contains one immunoglobulin-like C2-type domain and fourteen leucine-rich repeats and is glycosylated at various positions during post-translational modification. Lingo-3 is expressed in a broad but specific pattern in many tissues across the embryo. The gene encoding Lingo-3 maps to to human chromosome 19p13.3 and mouse chromosome 10 C1. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc alpha receptors. Subcellular Location: Membrane. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 11 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: P0C6S8 Gene ID: 645191 Database links: Entrez Gene: 645191 Human Entrez Gene: 237403 Mouse Entrez Gene: 690755 Rat Omim: 609792 Human SwissProt: P0C6S8 Human SwissProt: Q6GQU6 Mouse Unigene: 371587 Human Unigene: 40213 Mouse Unigene: 211966 Rat

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