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Product Name PENK(237-258) Chinese Name 脑啡肽A抗体 Alias EP-ENK; Enkephalin A; P ENK; Preproencephalin A; Proenkephalin A; Proenkephalin; Synenkephalin; Proenkephalin; Opioid growth factor; OGF; PENK protein; ProenkephalinA; PENK_HUMAN; Met-enkephalin-Arg-Gly-Leu; Met-enkephalin-Arg-Phe; Synenkephalin; PENK(114-133); PENK(143-183); PENK(237-258). Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PENK: 237-258/267 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Function:
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Subcellular Location:
Secreted.
Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Similarity:
Belongs to the opioid neuropeptide precursor family.
SWISS:
P01210
Gene ID:
5179
Database links:Entrez Gene: 5179 Human
Entrez Gene: 18619 Mouse
Omim: 131330 Human
SwissProt: P01210 Human
SwissProt: P22005 Mouse
Unigene: 339831 Human
Unigene: 475097 Mouse
Unigene: 10015 Rat
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