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Product Name Invadolysin Chinese Name Leishmanolysin样肽酶抗体 Alias Gp63; GP63 like; INV; LMLN_HUMAN; IX14; Leishmanolysin Like Peptidase; leishmanolysin-like (metallopeptidase M8 family); LMLN; Msp. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 74kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Invadolysin: 51-150/655 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Function:
Invadolysin, also known as Leismanolysin-Like proteinase, is a metalloproteinase of the MA clan, family M8, which is distinguished from the other families of metalloproteinases by an insert in the zinc binding site. The “classical” zinc binding motif of HExxHxxxxH contains an insert of 65 residues in the Leishmania form of Leishmanolysin, and varies from 62-105 residues amongst different parasite leishmanolysin isoforms.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Expressed in all cell lines analyzed.
Similarity:
Belongs to the peptidase M8 family.
SWISS:
Q96KR4
Gene ID:
89782
Database links:Entrez Gene: 89782 Human
Omim: 609380 Human
SwissProt: Q96KR4 Human
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