Product Name	TOE1
Chinese Name	早期生长应答蛋白1靶向蛋白1抗体
Alias	Target of EGR1 protein 1; target of EGR1, member 1; Toe1; TOE1_HUMAN.
Research Area	Cell biology  immunology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TOE1: 2-100/510
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TOE1 is a 510 amino acid long protein that belongs to the CAF1 family. It is a downstream target of EGR-1 and plays an important role mediating the inhibitory growth effect of EGR-1. EGR-1 directly binds the TOE1 promoter region and activates its expression. TOE1 induces the expression of TGF∫ and p21 and plays a role in cell cycle regulation and the inhibition of cell growth. The activity and nucleolar localization of TOE1 correlates with a G2 cell cycle phase delay which is likely due to an increased expression of p21. In addition, TOE1 may function via an interaction with p53 and possible modification to its activity. TOE1 is expressed at various levels in all adult tissues and specifically localizes to the nuclear speckles. Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Subcellular Location: Nucleus > nucleolus. Nucleus speckle. Localizes to nuclear speckles. Similarity: Belongs to the CAF1 family. Contains 1 C3H1-type zinc finger. SWISS: Q96GM8 Gene ID: 114034 Database links: Entrez Gene: 114034 Human Entrez Gene: 68276 Mouse Entrez Gene: 298443 Rat Omim: 613931 Human SwissProt: Q96GM8 Human SwissProt: Q9D2E2 Mouse Unigene: 525091 Human Unigene: 30534 Mouse Unigene: 105772 Rat

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