Product Name	HTRA3/Calpain 5
Chinese Name	钙蛋白酶5抗体
Alias	Calpain 5; Calpn 5; CAPN5; EC 3.4.21.; High temperature requirement factor A3; High-temperature requirement factor A3; HtrA serine peptidase 3; HTRA3; HTRA3_HUMAN; Pregnancy related serine protease; Pregnancy-related serine protease; Probable serine protease HTRA3; Probable serine protease HTRA3 precursor; PRSP; Serine protease HTRA3; Tasp.
literatures	Specific References  (1)     |     SL18100R has been referenced in 1 publications. [IF=2.682] Huang Wenying. et al. Study on the Correlation between the Levels of HtrA3 and TGF-β2 in Late Pregnancy and Preeclampsia. J Healthc Eng. 2022;2022:4453646  Other ;  Other.   PubMed:35035835
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HTRA3/Calpain 5: 61-160/453
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HtrA3 is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Function: Probable serine protease. Subcellular Location: Secreted. Tissue Specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. Similarity: Belongs to the peptidase S1B family. Contains 1 IGFBP N-terminal domain. Contains 1 Kazal-like domain. Contains 1 PDZ (DHR) domain. SWISS: P83110 Gene ID: 94031 Database links: Entrez Gene: 94031 Human Entrez Gene: 360959 Rat Omim: 608785 Human SwissProt: P83110 Human SwissProt: D3ZA76 Rat Unigene: 479119 Human

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