Product Name	GPR14
Chinese Name	G protein-coupled receptor14抗体
Alias	G protein coupled receptor 14; Urotensin II receptor (UR II R); UTR; UTR2; UTS2R; G Protein Coupled Receptor 14; GPCR GPR14; Urotensin II receptor; UR-II-R; UR-2-R; G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; SENR; GPR14; UR2R_HUMAN; GPCR GPR14.
literatures	Specific References  (1)     |     SL1806R has been referenced in 1 publications. [IF=16.806] Bo Gao. et al. Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration. 2022 Feb 23  IF ;  Human.   PubMed:10.1002/advs.202104888
Research Area	Cell biology  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human UTS2R: 101-200/389 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GPCR GPR14 has been reported to be expressed at high levels in the heart and pancreas and also in artery and smooth muscle. Low transcript levels have been identified in brain, particularly in thalamus, superior occipital gyrus, and substantia nigra. GPR14 is a high affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. Referenced from Swiss-Prot Q9UKP6. Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Most abundant expression in the heart and pancreas. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q9UKP6 Gene ID: 2837 Database links: Entrez Gene: 2837 Human Entrez Gene: 217369 Mouse Entrez Gene: 57305 Rat Omim: 600896 Human SwissProt: Q9UKP6 Human SwissProt: Q8VIH9 Mouse SwissProt: P49684 Rat Unigene: 192720 Human Unigene: 20122 Mouse Unigene: 44230 Rat
Product Picture	Blank control:U937. Primary Antibody (green line): Rabbit Anti-GPR14 antibody (SL1806R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells wereincubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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