Product Name	MRFAP1L1
Chinese Name	Tlymphocyte活化蛋白样蛋白MRFAP1L1抗体
Alias	MORF4 family-associated protein 1-like 1; MR1L1_HUMAN; MRFAP1L1; PP784. RBP1_HUMAN
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MRFAP1L1: 31-100/127
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. MORF4 family-associated protein 1 (MRFAP1), also known as GAM14 or PGR1, is a 127 amino acid member of the MORF4 family-associated protein family. Localized to nucleus and cytoplasm, MRFAP1 colocalizes with MORF4L1 to the cell nuclei. Its association with MORF4L1 and Rb1 suggests that MRFAP1 may play a role in transcription regulation. The gene encoding human MRFAP1 maps to chromosome 4p16.1. Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX)and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. Subunit: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Subcellular Location: Membrane Tissue Specificity: Expressed ubiquitously but at low levels.Shows a strong expression in the erythrocytes. Similarity: Belongs to the MORF4 family-associated protein family. SWISS: Q96HT8 Gene ID: 114932 Database links: Entrez Gene: 114932 Human SwissProt: Q96HT8 Human Unigene: 593159 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MRFAP1L1) Polyclonal Antibody, Unconjugated (SL17755R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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