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Product Name MOG1 Chinese Name RanBinding proteinMOG1抗体 Alias DKFZp686F02139; homolog of yeast MOG1; HSPC165; HSPC236; likely ortholog of mouse RAN guanine nucleotide release factor; MGC110973; MOG 1; MOG1; MOG1 homolog; MOG1_HUMAN; RAN guanine nucleotide release factor; Ran-binding protein MOG1; RANGNRF; RANGRF. Research Area Cardiovascular Cell biology Signal transduction Binding protein G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 20kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MOG1: 81-150/186 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Function:
May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.
Subunit:
Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.
Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm.
Tissue Specificity:
Isoform 1 and isoform 2 are ubiquitously expressed.
Similarity:
Belongs to the MOG1 family.
SWISS:
Q9HD47
Gene ID:
29098
Database links:Entrez Gene: 29098 Human
Entrez Gene: 57785 Mouse
Omim: 607954 Human
SwissProt: Q9HD47 Human
SwissProt: Q9JIB0 Mouse
Unigene: 408233 Human
Unigene: 371612 Mouse
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MOG1) Polyclonal Antibody, Unconjugated (SL17704R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MOG1) Polyclonal Antibody, Unconjugated (SL17704R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.Paraformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MOG1) Polyclonal Antibody, Unconjugated (SL17704R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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