Product Name	Elastin
Chinese Name	弹性蛋白抗体
Alias	alpha Elastin/Tropoelastin; Elastin isoform a; ELN; ELN_HUMAN; elastin isoform m precursor; FLJ38671; FLJ43523; Supravalvular aortic stenosis; Tropoelastin; Williams Beuren syndrome; Williams syndrome region; ADCL1; SVAS; WBS; WS.
literatures	Specific References  (7)     |     SL1756R has been referenced in 7 publications. [IF=6.87] Konii, Hanae, et al. "Stimulatory Effects of Cardiotrophin 1 on Atherosclerosis."Hypertension?(2013): HYPERTENSIONAHA-113  WB ;  Human.   PubMed:24041953 [IF=6.17] Tong Xu. et al. Lithium chloride represses abdominal aortic aneurysm via regulating GSK3β/SIRT1/NF-κB signaling pathway. Free Radical Bio Med. 2021 Apr;166:1  WB ;  Rat.   PubMed:33588051 [IF=3.998] Akira Minami. et al. Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2. Sci Rep-Uk. 2021 Feb;11(1):1-9  IHC ;  Rat.   PubMed:33558588 [IF=3.55] Guo, Hong-Feng, et al. "Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications." Colloids and Surfaces B: Biointerfaces (2012).  WB ;  Mouse.   PubMed:22503631 [IF=3.297] Hao Chen. et al. MicroRNA-124-3p affects myogenic differentiation of adipose-derived stem cells by targeting Caveolin-1 during pelvic floor dysfunction in Sprague Dawley rats. Ann Transl Med. 2021 Jan; 9(2): 161  WB ;  Rat.   PubMed:33569463 [IF=2.81] Hasegawa et al. Vasoprotective effects of urocortin 1 against atherosclerosis in vitro and in vivo. (2014) PLoS.On. 9:e110866  WB ;  Human.   PubMed:25462164 [IF=2.24] Mi Hee Kwack. et al. Efficacy of a home-used high-intensity focused ultrasound device on wrinkle reduction. SKIN RES TECHNOL. 2022 Dec;29(1):e13266  IHC ;  Mouse.   PubMed:36704876
Research Area	Tumour  immunology  Neurobiology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	70kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Elastin: 681-786/786
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]. Function: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Subunit: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Subcellular Location: Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers. Tissue Specificity: Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin. DISEASE: Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1) . A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Similarity: Belongs to the elastin family. SWISS: P15502 Gene ID: 2006 Database links: Entrez Gene: 2006 Human Entrez Gene: 13717 Mouse Omim: 130160 Human SwissProt: P15502 Human SwissProt: P54320 Mouse Unigene: 647061 Human
Product Picture	Sample: Lane 1: Uterus (Mouse) Lysate at 40 ug Lane 2: Lung (Mouse) Lysate at 40 ug Lane 3: Liver (Mouse) Lysate at 40 ug Lane 4: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 5: Lung (Rat) Lysate at 40 ug Lane 6: Liver (Rat) Lysate at 40 ug Lane 7: Testis (Rat) Lysate at 40 ug Lane 8: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 9: A549 (Human) Cell Lysate at 30 ug Primary: Anti-Elastin (SL1756R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 66 kD Observed band size: 68 kD Sample: Lung (Mouse) Lysate at 30 ug Primary: Anti- alpha Elastin/Tropoelastin (SL1756R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/10000 dilution Predicted band size: 70 kD Observed band size: 68 kD Images provided the Independent Validation Program (badge number 28751): Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti-alpha Elastin Polyclonal Antibody (SL1756R) at 1:1000 4℃ temperature overnight 4℃followed by conjugation to secondary antibody. The figure annotation: The blue histogram is unstained cells.The green histogram is cells stained with Rabbit Anti-alpha Elastin/Tropoelastin antibody (SL1756R)plus secondary antibody. Controls: Positive control: A549 cells .Isotype control: Cell lines treated with rabbit IgG (SL0295P)instead of the primary antibody to confirm that primary antibody binding is specific.Secondary only control: Both cell lines treated with Goat Anti-rabbit IgG/FITC antibody (SL0295G-FITC) to confirm no background signal produced from secondary antibody alone. 1ug in 100uL 1 X PBS containing 0.5% BSA.

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