Product Name	SKIV2L2
Chinese Name	ATP依赖的解旋酶SKIV2L2抗体
Alias	2610528A15Rik; ATP dependent helicase SKIV2L2; Dob1; SK2L2_HUMAN; KIAA0052; MGC142069; mKIAA0052; Mtr4; superkiller viralicidic activity 2 like 2 (S. cerevisiae); Superkiller viralicidic activity 2 like 2.
Research Area	Cell biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	117kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SKIV2L2: 901-1042/1042
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SKIV2L2, or superkiller viralicidic activity 2 like 2, may be involved in pre-mRNA splicing. SKIV2L2 is an exosome-associated protein and may be involved in the recruitment of the exosome to pre-rRNA, to mediate the 3' end processing of 5.8S rRNA. Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. Subunit: Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex. Subcellular Location: Nucleus, nucleoplasm. Nucleus, nucleolus. Similarity: Belongs to the helicase family. SKI2 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. SWISS: P42285 Gene ID: 23517 Database links: Entrez Gene: 23517 Human Entrez Gene: 72198 Mouse SwissProt: P42285 Human SwissProt: Q9CZU3 Mouse Unigene: 274531 Human

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