Product Name	SKT
Chinese Name	SKT蛋白抗体
Alias	DKFZP761L0424; KIAA1217; Likely orthologue of Mus musculus enhancer trap locus 4; Sickle tail protein homolog; SKT; SKT_HUMAN.
Research Area	Cell biology  Developmental biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	214kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SKT: 1701-1800/1943
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SKT is a 1,943 amino acid protein that localizes to cytoplasm. The SKT protein is required for normal development of intervertebral disks. Existing as seven alternatively spliced isoforms, the SKT gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 10p12.2. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. Function: Required for normal development of intervertebral disks. Subcellular Location: Cytoplasm. SWISS: Q5T5P2 Gene ID: 56243 Database links: Entrez Gene: 56243 Human SwissProt: Q5T5P2 Human Unigene: 445885 Human

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