Product Name	SIDT2
Chinese Name	SIDT2蛋白抗体
Alias	SIDT-2; B930096O19; BC023957; CGI 40; DKFZp686L17253; FLJ90656; MGC36407; MGC58967; RGD1308311; SID1 transmembrane family member 2; SID1 transmembrane family, member 2; SIDT2; SIDT2_HUMAN.
Research Area	Tumour  Cell biology  Channel protein  Transmembrane protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	93kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SIDT2: 201-300/832 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SID-1 and SID-2 belong to the systemic RNA interference defective-1 (SID1) family of transmembrane proteins. SID-1, originally identified in C. elegans, is an 827 amino acid long protein. It localizes to the cell membrane and contains eleven transmembrane domains. This suggests that SID-1 possibly functions as a channel protein. The overexpression of SID-1 enhances double stranded RNA (dsRNA) uptake in pancreatic ductal adenocarcinoma cells. SID-2, also first identified in C. elegans, is an 832 amino acid long protein with multiple transmembrane domains. At least two isoforms exist for SID-2 due to alternative splicing. Isoform 2 contains an additional 21 amino acids after residue 387 and has an alternate sequence that is 8 amino acids shorter for residues 814 to 832 of isoform 1. Subcellular Location: Lysosome membrane. Post-translational modifications: Glycosylated. Similarity: Belongs to the SID1 family. SWISS: Q8NBJ9 Gene ID: 51092 Database links: Entrez Gene: 51092 Human Entrez Gene: 214597 Mouse Entrez Gene: 315617 Rat SwissProt: Q8NBJ9 Human SwissProt: Q8CIF6 Mouse SwissProt: D3ZEH5 Rat Unigene: 712144 Human Unigene: 379345 Mouse Unigene: 162997 Rat
Product Picture	Sample: Panc-1(Human) Cell Lysate at 30 ug Primary: Anti- SIDT2 (SL17485R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 93 kD Observed band size: 98 kD

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