Product Name	SIDT1
Chinese Name	SIDT1蛋白抗体
Alias	AW045928; B830021E24Rik; FLJ20174; Msid2; OTTMUSP00000032144; SID 1; SID1; SID-1; SID1 transmembrane family member 1; SID1 transmembrane family, member 1; SIDT1; SIDT1_HUMAN.
Research Area	Tumour  Cell biology  Transmembrane protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SIDT1: 61-160/827 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SID-1 and SID-2 belong to the systemic RNA interference defective-1 (SID1) family of transmembrane proteins. SID-1, originally identified in C. elegans, is an 827 amino acid protein. It localizes to the cell membrane and contains eleven transmembrane domains. This suggests that SID-1 possibly functions as a channel protein. The overexpression of SID-1 enhances double stranded RNA (dsRNA) uptake in pancreatic ductal adenocarcinoma cells. SID-2, also first identified in C. elegans, is an 832 amino acid protein with multiple transmembrane domains. At least two isoforms exist for SID-2 due to alternative splicing. Isoform 2 contains an additional 21 amino acids after residue 387 and has an alternate sequence that is 8 amino acids shorter for residues 814 to 832 of isoform 1. Subcellular Location: Membrane. Similarity: Belongs to the SID1 family. SWISS: Q9NXL6 Gene ID: 54847 Database links: Entrez Gene: 54847 Human Entrez Gene: 320007 Mouse Entrez Gene: 288109 Rat Omim: 606816 Human SwissProt: Q9NXL6 Human SwissProt: Q6AXF6 Mouse SwissProt: Q6Q3F5 Rat Unigene: 591291 Human Unigene: 242144 Mouse Unigene: 51246 Rat

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