Product Name	Dopamine D5 receptor
Chinese Name	多巴胺受体D5抗体
Alias	D(1B) dopamine receptor; D(5) dopamine receptor; D1 beta dopamine receptor; D1B dopamine receptor; D1beta dopamine receptor; D5 dopamine receptor; DBDR; Dopamine receptor D1B; DRD 1B; DRD 5; DRD1B; DRD1L2; DRD5; MGC10601; DRD5_HUMAN; DRD5_RAT.
literatures	Specific References  (6)     |     SL1747R has been referenced in 6 publications. [IF=11.685] Kristine Elisabeth Eberhard. et al. Neurotransmitter and Neurotransmitter Receptor Expression in the Saccule of the Human Vestibular System. Prog Neurobiol. 2022 Jan;:102238  IHC ;  Human.   PubMed:35104536 [IF=8.101] Linlin Meng. et al. Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells. FREE RADICAL BIO MED. 2023 Jun;202:2  IHC ;  Mouse.   PubMed:36965538 [IF=4.522] Fujino S et al. Expression and function of dopamine in odontoblasts. J Cell Physiol. 2019 Oct 15.  IHC-P&WB ;  Rat.   PubMed:31612496 [IF=4.181] Bai L et al. m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite.Toxicol Sci. 2018 Oct 1;165(2):431-446.  WB ;  Mouse.   PubMed:29982692 [IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014).  WB ;  Human.   PubMed:24909515 [IF=0] Hardt, Olaf, et al. "SSEA4 AND ST3GAL2 AS CHEMOTHERAPEUTIC DRUG RESPONSE BIOMARKERS." U.S. Patent No. 20,150,316,556. 5 Nov. 2015.  FCM ;  Mouse.   PubMed:US Patent No20150335744
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat DRD5: 251-350/475
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This receptor is neuron specific, localized primarily within limbic regions of the brain. Defects in DRD5 are a cause of blepharospasm and may be a cause of schizophrenia. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Neuron-specific, localized primarily within limbic regions of the brain. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25115 Gene ID: 25195 Database links: Entrez Gene: 1816 Human Entrez Gene: 13492 Mouse Entrez Gene: 25195 Rat Omim: 126453 Human SwissProt: P21918 Human SwissProt: Q8BLD9 Mouse SwissProt: P25115 Rat Unigene: 380681 Human Unigene: 167154 Mouse Unigene: 138110 Rat
Product Picture	Sample: Brain (Mouse) Lysate at 40 ug Testis (Mouse) Lysate at 40 ug Primary: Anti- Dopamine D5 receptor (SL1747R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53kD Observed band size: 53kD Sample: Skin(Mouse) Lysate at 40 ug Skin(Rat) Lysate at 40 ug Primary: Anti-Dopamine D5 receptor (SL1747R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD Blank control: RSC96(blue). Primary Antibody:Rabbit Anti- DRD5 antibody(SL1747R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. Protocol The cells were fixed with 2% paraformaldehyde (10 min) . Antibody (SL1747R, 1μg /1x10^6 cells) were incubated for 30 min on the ice, followed by 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions. Then the Goat Anti-rabbit IgG/PE antibody was added into the blocking buffer mentioned above to react with the primary antibody of SL1747R at 1/200 dilution for 30 min on ice. Acquisition of 20,000 events was performed.

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