Product Name	Dopamine D3 receptor
Chinese Name	多巴胺受体D3抗体
Alias	DRD3; 3dopamine receptor; D; Dopamine receptor D3; DRD3; Dopamine receptor 3; ETM1; FET1; D(3) dopamine receptor; DRD3; DRD3_HUMAN.
literatures	Specific References  (6)     |     SL1743R has been referenced in 6 publications. [IF=6.05] Andrew Kisling. et al. Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro. Front Cardiovasc Med. 2021; 8: 732282  IF ;  Mouse.   PubMed:34708087 [IF=5.108] Yang K et al. Synaptic dopamine release is positively regulated by SNAP-25 that involves in benzo [a] pyrene-induced neurotoxicity. Chemosphere. 2019 Jul 15;237:124378.  IHC-P,ICF&WB ;  Rat.   PubMed:31376700 [IF=4.831] Shi L et al. Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson's disease through AKT/mTOR pathway. Aging (Albany NY) . 2020 May 18;12(10):9515-9533.  WB ;  Monkey.   PubMed:32424108 [IF=4.432] Ting Li. et al. Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system. Eur J Pharmacol. 2021 Nov;910:174443  WB ;  Rat.   PubMed:34464604 [IF=4.181] Bai L et al. m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite.Toxicol Sci. 2018 Oct 1;165(2):431-446.  WB ;  Mouse.   PubMed:29982692 [IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014).  WB ;  Human.   PubMed:24909515
Research Area	Cell biology  Neurobiology  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse DRD3: 352-446/446 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Also known as: dopamine D3 receptor; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1. Subunit: Interacts with CLIC6. Interacts with GRK4. Interacts with PALM. Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Tissue Specificity: Brain. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P30728 Gene ID: 13490 Database links: Entrez Gene: 1814 Human Entrez Gene: 13490 Mouse Entrez Gene: 29238 Rat Omim: 126451 Human SwissProt: P35462 Human SwissProt: P30728 Mouse SwissProt: P19020 Rat Unigene: 121478 Human Unigene: 439735 Mouse Unigene: 10356 Rat 多巴胺受体D3常与某些精神、神经疾病有关，如精神分裂症、早发性痴呆等。但最新研究表明多巴胺受体与Tumour细胞多药耐药有关。
Product Picture	Sample: Brain (Mouse) Lysate at 40 ug Brain (Rat) Lysate at 40 ug Primary: Anti-Dopamine D3 receptor (SL1743R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 44 kD Observed band size: 48 kD Sample: HepG2 Cell Lysate at 30 ug U251 Cell Lysate at 30 ug Primary: Anti-Dopamine D3 receptor (SL1743R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 44 kD Observed band size: 48 kD Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Dopamine D3 receptor) Polyclonal Antibody, Unconjugated (SL1743R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Dopamine D3 receptor) Polyclonal Antibody, Unconjugated (SL1743R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF594) for 90 minutes, and DAPI for nuclei staining.

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