Product Name	HP1BP3
Chinese Name	异染色质蛋白1Binding protein3抗体
Alias	Heterochromatin protein 1, binding protein 3; HP1 BP74; HP1BP 3; MGC28927; MGC43701; MGC72624; OTTHUMP00000002717; OTTHUMP00000002719; OTTHUMP00000002720; Protein HP1 BP74; RP5 930J4.3.
Research Area	Cell biology  Binding protein  Cell type markers  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HP1BP3: 301-400/553
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HP1BP3 is a 553 amino acid nuclear and chromosomal protein that exists as a component of heterochromatin. As such, HP1BP3 is involved in chromatin function and structure. Existing as four alternatively spliced isoforms, HP1BP3 undergoes post-translational phosphorylation, most likely by either ATM or ATR. HP1BP3 contains three H15 (linker histone H1/H5 globular) domains and is encoded by a gene that maps to human chromosome 1p36.12. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Function: HP1BP3 is a component of heterochromatin and may be involved in chromatin structure and function. Subcellular Location: Nuclear SWISS: Q5SSJ5 Gene ID: 50809 Database links: Entrez Gene: 50809 Human Entrez Gene: 15441 Mouse Entrez Gene: 313647 Rat SwissProt: Q5SSJ5 Human SwissProt: Q3TEA8 Mouse SwissProt: Q6P747 Rat
Product Picture	Sample: Jurkat cell(human) Lysate at 30 ug Panc1 cell(human) Lysate at 30 ug Primary: Anti- HP1BP3 (SL17375R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61kD Observed band size: 61kD Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HP1BP3) Polyclonal Antibody, Unconjugated (SL17375R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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