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Product Name TOMM22 Chinese Name TOMM22蛋白抗体 Alias 1C9 2; hTom 22; hTom22; Mitochondrial import receptor subunit TOM 22 homolog; Mitochondrial import receptor subunit TOM22 homolog; Mitochondrial import receptor Tom 22; Mitochondrial import receptor Tom22; MST 065; MST065; MSTP 065; MSTP065; TOM 22; TOM22_HUMAN; TOM22; TOMM 22; Translocase of outer membrane 22 kDa subunit homolog; Translocase of outer mitochondrial membrane 22 homolog. Research Area Cell biology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 15kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TOMM22: 51-142/142 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]
Function:
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.
Subunit:
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).
Subcellular Location:
Mitochondrion outer membrane; Single-pass membrane protein
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the Tom22 family.
SWISS:
Q9NS69
Gene ID:
56993
Database links:
Entrez Gene: 56993 Human
Entrez Gene: 223696 Mouse
Omim: 607046 Human
SwissProt: Q9NS69 Human
SwissProt: Q9CPQ3 Mouse
Unigene: 285005 Human
Unigene: 246435 Mouse
Product Picture Tissue/cell: rat colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TOMM22 Polyclonal Antibody, Unconjugated(SL17225R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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