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Product Name phospho-KIF20A (Ser528) Chinese Name 磷酸化有丝分裂驱动蛋白样2抗体 Alias KI20A_HUMAN; Kinesin-like protein KIF20A; MKLP2; RAB6KIFL; RCM6; GG10_2; Mitotic kinesin-like protein 2 (MKlp2); Rab6-interacting kinesin-like protein; Rabkinesin-6; kinesin family member 20A; Product Type Phosphorylated anti Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 100kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human KIF20A around the phosphorylation site of Ser528: EH(p-S)LQ Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Subcellular Location:
Golgi apparatus. Cytoplasm > cytoskeleton > spindle.
Post-translational modifications:
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
SWISS:
O95235
Gene ID:
10112
Database links:Entrez Gene: 10112 Human
Entrez Gene: 19348 Mouse
SwissProt: O95235 Human
SwissProt: P97329 Mouse
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