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Product Name CCL21 Chinese Name lymphocyteChemokineCCL21/Exodus 2抗体 Alias 6Ckine; Beta chemokine exodus 2; Beta chemokine exodus2; CCL 21; CCL21; Chemokine C C motif ligand 21; Chemokine CC motif ligand 21; CKb 9; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; Exodus 2; Exodus2; Exodus-2; SCYA 21; SCYA21; Secondary lymphoid tissue chemokine; SLC; Small inducible cytokine A21; Small inducible cytokine subfamily A (Cys Cys) member 21; Small inducible cytokine subfamily A (Cys-Cys) member 21; Small inducible cytokine subfamily A member 21; TCA 4; TCA4. literatures Specific References (6) | SL1666R has been referenced in 6 publications.[IF=17.521] Jiabin Xu. et al. CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy. Advanced Science. 2023 Apr;:2207017 IF ; Mouse.[IF=6.354] Hao, Yanan. et al. Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. MOL MED. 2022 Dec;28(1):1-17 IF ; Mouse.[IF=5.029] Hanhan Fang. et al. Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption | mSphere. MSPHERE. 2022 Dec;: IF ; Mouse.[IF=2.52] Expression of Pref-1 and Related Chemokines during theDevelopment of Rat Mesenteric Lymph Nodes.(2018)Biomed Environ Sci.ul;31(7):507-514. IHC ; Rat.[IF=2.23] Borrelli, G. M., et al. "Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes." Reproductive Sciences (2015): 1933719115592711. IHC-P ; Human.[IF=0] Borrelli, Giuliano. D6926. Diss. Freie Universität Berlin, 2015. IHC-P ; Human.Research Area Tumour Cell biology immunology transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 15kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CCL21: 24-134/134 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Jul 2008].
Function:
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.
DISEASE:
Note=Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
O00585
Gene ID:
6366
Database links:Entrez Gene: 6366 Human
Omim: 602737 Human
SwissProt: O00585 Human
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