Product Name	TOR3A/ADIR2
Chinese Name	ATP依赖的Interferon反应蛋白1抗体
Alias	ADIR; ADIR2; ATP dependant interferon response protein 1; ATP dependant interferon responsive; ATP dependent interferon responsive protein; ATP-dependent interferon-responsive protein; FLJ22345; MGC111104; Tor3a; TOR3A_HUMAN; torsin 3A; Torsin family 3 member A; torsin family 3, member A; Torsin-3A torsin family 3, member A; Torsin3A;
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TOR3A: 311-397/397
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Torsin3A is a 397 amino acid member of the clpA/clpB family of proteins. Localized to the cytoplasm and the endoplasmic reticulum, Torsin3A is most highly expressed in stomach, lymph nodes and salivary glands. Torsin3A contains a hydrophobic N-terminal sequence, an ATP binding domain and 8 putative phosphorylation sites. Highly homologous with TorsinA and TorsinB, Torsin3A is thought to be related to the AAA chaperone-like family of ATPases. Members of this family play a role in the assembly, disassembly and operation of a variety of protein complexes, confer increased tolerance to high temperature and promote specific proteolysis. Torsin3A is also referred to as an interferon responsive gene, as interaction with type 1 interferons (IFN-alpha and IFN-beta) cause a 5 to 40 fold increase in Torsin3A mRNA levels. Three isoforms of Torsin3A exist as a result of alternative splicing events, and isoform 2 is expressed exclusively in the placenta Subcellular Location: Cytoplasm. Endoplasmic reticulum. Tissue Specificity: Ubiquitously expressed. Highest expression in stomach, salivary glands and lymph nodes. Isoform 2 is expressed in placenta. Similarity: Belongs to the clpA/clpB family. Torsin subfamily. SWISS: Q9H497 Gene ID: 64222 Database links: Entrez Gene: 64222 Human Entrez Gene: 30935 Mouse Entrez Gene: 304884 Rat Omim: 607555 Human SwissProt: Q9H497 Human SwissProt: Q9ER38 Mouse SwissProt: Q5M936 Rat Unigene: 584957 Human Unigene: 206737 Mouse Unigene: 2164 Rat
Product Picture	Sample: Siha(Human) Cell Lysate at 30 ug Primary: Anti- TOR3A/ADIR2 (SL16611R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kD Observed band size: 43 kD Paraformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TOR3A) Polyclonal Antibody, Unconjugated (SL16611R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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