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Product Name TNFR2 Chinese Name Tumour坏死因子受体2抗体 Alias TNF Receptor II; CD120b; p75; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; TBP-2; TBPII; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFR-II; TNFR80; TNFRII; TNFRSF1B; TNR1B_HUMAN; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2. Research Area Tumour Cell biology Neurobiology Signal transduction Apoptosis The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 46kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TNFR2: 201-300/461 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Location:
Secreted and Cell membrane.
Post-translational modifications:
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
Similarity:
Contains 4 TNFR-Cys repeats.
SWISS:
P20333
Gene ID:
7133
Database links:Entrez Gene: 7133 Human
Entrez Gene: 21938 Mouse
Omim: 191191 Human
SwissProt: P20333 Human
SwissProt: P25119 Mouse
Unigene: 256278 Human
Unigene: 235328 Mouse
Unigene: 83633 Rat
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