Product Name	ILF3
Chinese Name	白细胞介素增强子结合因子3抗体
Alias	CBTF; Double stranded RNA binding protein 76; Double-stranded RNA-binding protein 76; DRBF; DRBP76; ILF3; ILF3_HUMAN; Interleukin enhancer binding factor 3; Interleukin enhancer-binding factor 3; M phase phosphoprotein 4; M-phase phosphoprotein 4; MPHOSPH4; MPP4; NF AT 90; NF-AT-90; NF110; NF90; NFAR; Nuclear factor associated with dsRNA; Nuclear factor of activated T cells 90 kDa; Nuclear factor of activated T-cells 90 kDa; TCP80; Translational control protein 80
Research Area	Cell biology  transcriptional regulatory factor  Transporter  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ILF3: 1-100/894
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Subcellular Location: Nucleus; nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by RNA-dependent protein kinase (EIF2AK2). Methylated by protein arginine N-methyltransferase 1. Arg-609 is dimethylated, probably to asymmetric dimethylarginine. Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains. Contains 1 DZF domain. SWISS: Q12906 Gene ID: 3609 Database links: Entrez Gene: 3609 Human Entrez Gene: 614936 Cow Entrez Gene: 16201 Mouse Entrez Gene: 84472 Rat Entrez Gene: 321868 Zebrafish Omim: 603182 Human SwissProt: Q12906 Human SwissProt: Q9Z1X4 Mouse SwissProt: Q9JIL3 Rat SwissProt: Q6NXA4 Zebrafish Unigene: 465885 Human Unigene: 440026 Mouse Unigene: 203881 Rat

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