Product Name	TRAP5
Chinese Name	抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
Alias	Tartrate Resistant Acid Phosphatase; Acid phosphatase 5, tartrate resistant; ACP5; EC 3.1.3.2; PPA5_HUMAN; serum band 5 tartrate-resistant acid phosphatase; SPENCDI; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR-AP; TRACP 5; TRAP; TrATPase; Type 5 acid phosphatase.
literatures	Specific References  (2)     |     SL16578R has been referenced in 2 publications. [IF=7.419] Xiaoyu Cai. et al. Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis. BIOMED PHARMACOTHER. 2022 Nov;155:113687  FC ;  Mouse.   PubMed:36088855 [IF=6.208] Cong-Jin Liu. et al. Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products. INT J MOL SCI. 2023 Jan;24(5):4953  IF ;  Rat.   PubMed:36902384
Research Area	Tumour  Cell biology  immunology  Signal transduction  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TRAP5: 171-270/325
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008] Function: Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Subcellular Location: Lysosome. Similarity: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. SWISS: P13686 Gene ID: 54 Database links: Entrez Gene: 54 Human Omim: 171640 Human SwissProt: P13686 Human Unigene: 1211 Human

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