Product Name	HDGFRP3
Chinese Name	肝癌衍生生长因子相关蛋白3抗体
Alias	CGI 142; HDGF 2; HDGF-2; HDGF2; HDGFRP 3; Hdgfrp3; HDGR3_HUMAN; Hepatoma derived growth factor 2; Hepatoma derived growth factor related protein 3; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor-related protein 3; HRP 3; HRP-3; HRP3.
Research Area	Tumour  Neurobiology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDGFRP3: 101-203/203
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Hepatoma derived growth factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells, where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are expressed only in testis, while HRP-2 is widely expressed in different tissues. HRP-3 can be found solely in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex, while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis and cerebellum. In the central nervous system, HRPs play a role in neuron proliferation and cell survival. Function: Enhances DNA synthesis and may play a role in cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Detected in testis, heart, spinal cord and brain. Similarity: Belongs to the HDGF family. Contains 1 PWWP domain. SWISS: Q9Y3E1 Gene ID: 50810 Database links: Entrez Gene: 50810 Human Entrez Gene: 29877 Mouse Entrez Gene: 252941 Rat SwissProt: Q9Y3E1 Human SwissProt: Q9JMG7 Mouse SwissProt: Q923W4 Rat Unigene: 513954 Human Unigene: 392934 Mouse Unigene: 17383 Rat

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